Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 105, Issue -, Pages 20-34Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.08.008
Keywords
Synthetic biology; Genetic circuits; Cell therapy; Gene networks
Categories
Funding
- University of Utah startup funds
- National Science Foundation CAREER Program
- Office of Naval Research Young Investigator Program
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1554017] Funding Source: National Science Foundation
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Advances in synthetic biology have enabled the engineering of cells with genetic circuits in order to program cells with new biological behavior, dynamic gene expression, and logic control. This cellular engineering progression offers an array of living sensors that can discriminate between cell states, produce a regulated dose of therapeutic biomolecules, and function in various delivery platforms. In this review, we highlight and summarize the tools and applications in bacterial and mammalian synthetic biology. The examples detailed in this review provide insight to further understand genetic circuits, how they are used to program cells with novel functions, and current methods to reliably interface this technology in vivo; thus paving the way for the design of promising novel therapeutic applications. (C) 2016 Elsevier B.V. All rights reserved.
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