Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 105, Issue -, Pages 3-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.04.005
Keywords
Molecular diagnostics; Nucleic acid tests; PCR; Hybridization; Next-generation sequencing
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Funding
- Cancer Prevention Research Institute of Texas (CPRIT) award [RP140132]
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Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics. (C) 2016 The Authors. Published by Elsevier B.V.
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