Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 106, Issue -, Pages 148-156Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.02.006
Keywords
Extracellular vesicles; exosomes; microvesicles; drug delivery; isolation; biodistribution; targeting; nanomedicine
Categories
Funding
- VENI Fellowship from the Netherlands Organisation for Scientific Research (NWO) [13667]
- Dutch Ministry of Economic Affairs, Agriculture and Innovation
- Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart Foundation
- Dutch Federation of University Medical Centers
- Netherlands Organization for Health Research and Development
- Royal Netherlands Academy of Sciences
- European Research Council starting grant MINDS in the FP7 ideas program of the European Union [260627]
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Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained considerable scientific interest. EVs may have multiple advantages over currently available drug delivery vehicles, such as their ability to overcome natural barriers, their intrinsic cell targeting properties, and stability in the circulation. However, therapeutic applications of EVs as drug delivery systems have been limited due to a lack of methods for scalable EV isolation and efficient drug loading. Furthermore, in order to achieve targeted drug delivery, their intrinsic cell targeting properties should be tuned through EV engineering. Here, we review and discuss recent progress and remaining challenges in the development of EVs as drug delivery vehicles. (C) 2016 Elsevier B.V. All rights reserved.
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