Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 102, Issue -, Pages 102-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.04.012
Keywords
Anti-tuberculosis drugs; Drug delivery systems; Nanoparticles; Pulmonary administration; Oral administration; Skin administration; Targeting
Categories
Funding
- FCT (Fundacao para a Ciencia e Tecnologia) [SFRH/BD/95227/2013, SFRH/BPD/99124/2013]
- FCT from the International Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (BiotechHealth) [PD/BI/105907/2014]
- European Regional Development Fund (ERDF) through the Programa Operational Factores de Competitividade - COMPETE
- Portuguese funds through FCT [PEst-C/SAU/LA0002/2013]
- North Portugal Regional Operational Programme (ON.2 - O Novo Norte)
- Fundação para a Ciência e a Tecnologia [PD/BI/105907/2014, SFRH/BD/95227/2013, SFRH/BPD/99124/2013] Funding Source: FCT
Ask authors/readers for more resources
Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide, alongside the human immunodeficiency virus (HIV) infection. The current treatment is effective, but is associated with severe adverse-effects and noncompliance to prescribed regimens. An alternative route of drug delivery may improve the performance of existing drugs, which may have a key importance in TB control and eradication. Recent advances and emerging technologies in nanoscale systems, particularly nanoparticles (NPs), have the potential to transform such approach to human health and disease. Until now, several nanodelivery systems for the pulmonary administration of anti-TB drugs have been intensively studied and their utility as an alternative to the classical TB treatment has been suggested. In this context, this review provides a comprehensive analysis of recent progress in nanodelivery systems for pulmonary administration of anti-TB drugs. Additionally, more convenient and cost-effective alternatives for the lung delivery, different types of NPs for oral and topical are also being considered, and summarized in this review. Lastly, the future of this growing field and its potential impact will be discussed. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available