Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 107, Issue -, Pages 213-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.07.002
Keywords
Poly(lactic acid); PLA copolymers; Injectable depot; Microspheres; PLA clinical products
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Poly(lactic acid) and its copolymers have revolutionized the field of drug delivery due to their excellent biocompatibility and tunable physico-chemical properties. These copolymers have served the healthcare sector by contributing many products to combat various diseases and for biomedical applications. This article provides a comprehensive overview of clinically used products of poly(lactic acid) and its copolymers. Multi-dimension information covering product approval, formulation aspects and clinical status is described to provide a panoramic overview of each product. Moreover, leading patented technologies and various clinical trials on these products for different applications are included. This review focuses on marketed injectable formulations of PLA and its copolymers. (C) 2016 Elsevier B.V. All rights reserved.
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