Journal
MICROBIOME
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s40168-018-0598-x
Keywords
Faecal microbiota transplantation; Bacteriophages; Viruses; Engraftment; Persistence; Donor-recipient
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Funding
- Science Foundation Ireland [SFI/12/RC/2273]
- Academy of Finland [258439, 283088, 304490]
- University of Helsinki
- Sigrid Juselius Foundation
- Paulo and Sohlberg Foundation
- Helsinki and Uusimaa Hospital District
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BackgroundFaecal microbiota transplantation (FMT) is used in the treatment of recurrent Clostridium difficile infection. Its success is typically attributed to the restoration of a diverse microbiota. Viruses (including bacteriophages) are the most numerically dominant and potentially the most diverse members of the microbiota, but their fate following FMT has not been well studied.ResultsWe studied viral transfer following FMT from 3 donors to 14 patients. Recipient viromes resembled those of their donors for up to 12months. Tracking individual bacteriophage colonisation revealed that engraftment of individual bacteriophages was dependent on specific donor-recipient pairings. Specifically, multiple recipients from a single donor displayed highly individualised virus colonisation patterns.ConclusionsThe impact of viruses on long-term microbial dynamics is a factor that should be reviewed when considering FMT as a therapeutic option.
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