Journal
MATERIALS RESEARCH EXPRESS
Volume 6, Issue 1, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/2053-1591/aae7c6
Keywords
BiOI; ultrasmall nanoparticle; polyol method; x-ray attenuation; contrast agent
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Funding
- Basic Science Research Program of the National Research Foundation - Ministry of Education, Science, and Technology, South Korea [2017R1A2B3003214, 2016R1D1A3B01007622]
- Basic Research Laboratory (BRL) Program of the National Research Foundation - Ministry of Education, Science, and Technology, South Korea [2013R1A4A1069507]
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A polyol method is extremely useful for preparimg metal-containing nanoparticles coated with hydrophilic and biocompatible ligands for biomedical applications. In this study, D-glucuronic acid-coated BiOI nanoparticles were prepared in one-pot using this method. The particle diameter was controlled by varying the solvent volume such that the particle diameter decreased with increasing solvent volume: nanoparticles with average diameters of 1.9 (ultrasmall) and 6.1 nm were prepared at two solvent volumes. The x-ray attenuation properties of the ultrasmall nanoparticles were investigated because of their suitability for in vivo biomedical applications. D-glucuronic acid-coated ultrasmall BiOI nanoparticles were superior to the commercial molecular iodine contrast agent Ultravist((R)) in terms of x-ray attenuation, and showed the highest x-ray attenuation efficiency (eta) of similar to 21 HU/mM [Bi] that has ever been reported thus far, proving their potential as an extremely powerful x-ray contrast agent.
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