Adsorption of antitumor antibiotic doxorubicin on MCM-41-type silica surface

The aim of this study was to evaluate the adsorption behavior of doxorubicin on MCM-41 silica, which was synthesized by templated sol-gel method, as a function of contact time, pH of solution, and drug equilibrium concentration. Experimental kinetic curves of adsorption were compared with theoretical models of Lagergren and Ho-McKay for pseudo-first-and pseudo-second-order processes. Equilibrium adsorption of doxorubicin was analyzed by Langmuir, Freundlich, RedlichPeterson, and Brunauer-Emmet-Teller isotherm models. These results can be the basis for direct modification of MCM-41-type silicas sorption activity to drugs.