Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02827
Keywords
resident memory T cells; chronic; inflammation; infection; autoimmune
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Tissue-resident-memory CD8+ T cells (T-RM) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While T-RM in all non-lymphoid organs probably share a core signature differentiation pathway, certain aspects of their maintenance and effector functions may vary. It is well-established that T-RM provide long-lived protective immunity through immediate effector function and accelerated recruitment of circulating immune cells. Besides immune defense against pathogens, other immunological roles of T-RM are less well-studied. Likewise, evidence of a putative detrimental role of T-RM for inflammatory diseases is only beginning to emerge. In this review, we discuss the protective and harmful role of T-RM in organ-specific immunity and immunopathology as well as prospective implications for immunomodulatory therapy.
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