Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02334
Keywords
autophagy; ATG5; autoimmune disease; apoptosis; immunity
Categories
Funding
- National Key Research and Development Program of China [2016YFC0904102]
- National Science Foundation of China [81570629]
- Training Program of the Major Research Plan of the National Natural Science Foundation of China [91642120]
- Natural Science Foundation for Innovation Research Group of China [81621092]
- Beijing Nova Program [Z171100001117023]
- University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research [BMU2017JI007]
- Beijing Youth Top-notch Talent Support Program [2017000021223ZK31]
- Chinese Society of Nephrology [15020030591]
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Autophagy is a highly conserved process that degrades certain intracellular contents in both physiological and pathological conditions. Autophagy-related proteins (ATG) are key players in this pathway, among which ATG5 is indispensable in both canonical and non-canonical autophagy. Recent studies demonstrate that ATG5 modulates the immune system and crosstalks with apoptosis. However, our knowledge of the pathogenesis and regulatory mechanisms of autophagy in various immune related diseases is lacking. Thus, a deeper understanding of ATG5's role in the autophagy mechanism may shed light on the link between autophagy and the immune response, and lead to the development of new therapies for autoimmune diseases and autoinflammatory diseases. In this focused review, we discuss the latest insights into the role of ATG5 in autoimmunity. Although these studies are at a relatively early stage, ATG5 may eventually come to be regarded as a guardian of immune integrity. Notably, accumulating evidence indicates that other ATG genes may have similar functions.
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