Journal
FRONTIERS IN IMMUNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02964
Keywords
juvenile idiopathic arthritis (JIA); genetics; enhancer; non-coding genome; topically associated domains
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Funding
- National Institutes of Health [NIH R21- AR071878]
- Arthritis Foundation [6490]
- Rheumatology Research Foundation
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001412]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR001412] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R21AR071878] Funding Source: NIH RePORTER
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The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis. In this review, we discuss how new insights into genetic risk for JIA and the three dimensional architecture of the genome may be used to develop a better understanding of the mechanisms driving these gene expression patterns.
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