Journal
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 27, Issue 1, Pages 9-20Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s40199-018-0232-2
Keywords
Multi walled carbon nanotubes; Curcumin; Adsorption isotherm; Release; Drug delivery
Categories
Funding
- Universiti Teknologi Malaysia (UTM)
Ask authors/readers for more resources
Polyethylene glycol functionalized with oxygenated multi-walled carbon nanotubes (O-PEG-MWCNTs) as an efficient nanomaterial for the in vitro adsorption/release of curcumin (CUR) anticancer agent. The synthesized material was morphologically characterized using scanning electron microscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. In addition, the CUR adsorption process was assessed with kinetic and isotherm models fitting well with pseudo-second order and Langmuir isotherms. The results showed that the proposed O-PEG-MWCNTs has a high adsorption capacity for CUR (2.0x10(3)mg/g) based on the Langmuir model. The in vitro release of CUR from O-PEG-MWCNTs was studied in simulating human body fluids with different pHs (ABS pH5, intestinal fluid pH6.6 and body fluid pH7.4). Lastly, to confirm the success compliance of the O-PEG-MWCNT nanocomposite as a drug delivery system, the parameters affecting the CUR release such as temperature and PEG content were investigated. As a result, the proposed nanocomposite could be used as an efficient carrier for CUR delivery with an enhanced prolonged release property.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available