Journal
BIOCHIMIE
Volume 117, Issue -, Pages 37-47Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2015.05.005
Keywords
Viroids; RNA satellites; Hepatitis D virus; lncRNA
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Funding
- Greek 'Ministry of education and life-long learning' through NSRF/ESPA grants [Aristeia II-4499, Synergasia 09SYN_22_638]
- UCR Academic Senate [A01863]
- RSAP [19900NWAR]
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Long non protein coding RNAs (lncRNAs) constitute a large category of the RNA world, able to regulate different biological processes. In this review we are focusing on infectious lncRNAs, their classification, pathogenesis and impact on the infected organisms. Here they are presented in two separate groups: 'dependent lncRNAs' (comprising satellites RNA, Hepatitis D virus and lncRNAs of viral origin) which need a helper virus and 'independent lncRNAs' (viroids) that can self-replicate. Even though these lncRNA do not encode any protein, their structure and/or sequence comprise all the necessary information to drive specific interactions with host factors and regulate several cellular functions. These new data that have emerged during the last few years concerning lncRNAs modify the way we understand molecular biology's 'central dogma' and give new perspectives for applications and potential therapeutic strategies. (C) 2015 Published by Elsevier B.V.
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