Journal
ADVANCED SCIENCE
Volume 6, Issue 1, Pages -Publisher
WILEY
DOI: 10.1002/advs.201801526
Keywords
cancer therapy; drug delivery; metal-organic frameworks (MOFs); nanoparticles; stimuli responsive
Categories
Funding
- National Natural Science Foundation of China [81701769, 31470956, 81422023, 81371596, U1705281, U1505221]
- National Key Research and Development Program of China [2017YFA0205201, 2018YFA0107301]
- China Postdoctoral Science Foundation [2017M613127]
- Fundamental Research Funds for the Central Universities [xjj2017144, 20720160065, 20720150141]
- Research Support Program for Young Teachers in Xi'an Jiaotong University [YX1K075]
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM7031]
- Shaanxi Provincial Postdoctoral Science Foundation of China [2017BSHEDZZ96]
- Program for New Century Excellent Talents in University, China [NCET-13-0502]
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With the rapid development of nanotechnology, stimuli-responsive nanomaterials have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal-organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, recent progress in MOF-based stimuli-responsive systems is presented, including pH-, magnetic-, ion-, temperature-, pressure-, light-, humidity-, redox-, and multiple stimuli-responsive systems for the delivery of anticancer drugs. The remaining challenges and suggestions for future directions for the rational design of MOF-based nanomedicines are also discussed.
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