Journal
ADVANCED SCIENCE
Volume 5, Issue 12, Pages -Publisher
WILEY
DOI: 10.1002/advs.201800875
Keywords
adaptable hydrogels; drug delivery; positive feedback; tissue regeneration
Categories
Funding
- National Natural Science Foundation of China [31570979, 81572198, 81772394]
- General Research Fund grant from the Research Grants Council of Hong Kong [14202215, 14220716]
- Hong Kong Research Grants Council Theme-based Research Scheme [T13-402/17-N]
- Health and Medical Research Fund
- Food and Health Bureau
- Government of the Hong Kong Special Administrative Region [03140056]
- Chow Yuk Ho Technology Centre for Innovative Medicine
- Chinese University of Hong Kong, Fund for High Level Medical Discipline Construction of Shenzhen University [2016031638]
- Medical Research Foundation of Guangdong Province, China [A2016314]
- Shenzhen Science and Technology Projects [JCYJ20170306092215436, JCYJ20170412150609690, JCYJ20170413161800287, SGLH20161209105517753, JCYJ20160301111338144]
Ask authors/readers for more resources
The targeted and simultaneous delivery of diverse cargoes with vastly different properties by the same vehicle is highly appealing but challenging. Here, a bioactive nanocomposite hydrogel based on hyaluronic acid and self-assembled pamidronate-magnesium nanoparticles for the localized elution and on-demand simultaneous release of bioactive ions and small molecule drugs is described. The obtained nanocomposite hydrogels exhibit excellent injectability and efficient stress relaxation, thereby allowing easy injection and consequent adaptation of hydrogels to bone defects with irregular shapes. Magnesium ions released from the hydrogels promote osteogenic differentiation of the encapsulated human mesenchymal stem cells (hMSCs) and activation of alkaline phosphatase (ALP). The activated ALP subsequently catalyzes the dephosphorylation (activation) of Dex phosphate, a pro-drug of Dex, and expedites the release of Dex from hydrogels to further promote hMSC osteogenesis. This positive feedback circuit governing the activation and release of Dex significantly enhances bone regeneration at the hydrogel implantation sites. The findings suggest that these injectable nanocomposite hydrogels mediate optimized release of diverse therapeutic cargoes and effectively promote in situ bone regeneration via minimally invasive procedures.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available