Journal
ADVANCED SCIENCE
Volume 6, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/advs.201801122
Keywords
autophagy; mild photothermal therapy; NIR triggered; nitric oxide release; NO-sensitized synergistic therapy
Categories
Funding
- National Basic Research Program of China [2016YFA2021600, 2016YFA0202104]
- National Natural Science Foundation of China [51772292, 31571015, 11621505, 11435002, 21320102003]
- Chinese Academy of Sciences Youth Innovation Promotion Association [2013007]
Ask authors/readers for more resources
Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side-effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi2S3) nanoparticles and bis-N-nitroso compounds (BNN) are constructed for NO-enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on-demand NO release are realized simultaneously. Due to the unique properties of NO, enhanced antitumor efficacy of mild PTT based on BNN-Bi2S3 nanocomposites is achieved in vitro and in vivo. Mechanism studies reveal that the exogenous NO from BNN-Bi2S3 could not only impair the autophagic self-repairing ability of tumor cells in situ, but also diffuse to the surrounding cells to enhance the therapeutic effect. This work points out a strategy to overcome the difficulties in mild PTT, and has potentials for further exploitation of NO-sensitized synergistic cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available