Journal
ACS INFECTIOUS DISEASES
Volume 5, Issue 1, Pages 131-140Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.8b00246
Keywords
antibiotic resistance; metallo-beta-lactamase inhibitor; NDM-1; VIM-2; meropenem; efficacy
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Funding
- Wellcome Trust [099212/Z/12]
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The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-beta-lactamase (MBL) and serine-beta-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new beta-lactamase inhibitors to be used in conjunction with carbapenems and other beta-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-beta-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.
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