Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 5, Issue 8, Pages 3909-3921Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01307
Keywords
groove pattern; magnetic nanoparticles; hydrogel; wound healing; vascularization; angiogenesis
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Funding
- Ministry of Science, ICT and Future Planning [NRF-2016R1E1A1A01943393, NRF-2017M3A9C6031786, NRF-2017K1A3A1A19070731]
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Endothelial progenitor cells (EPCs) can induce a pro-angiogenic response during tissue repair. Recently, EPC transplantations have been widely investigated in wound healing applications. To maximize the healing efficacy by EPCs, a unique scaffold design that allows cell retention and function would be desirable for in situ delivery. Herein, we fabricated an alginate/poly-L-ornithine/gelatin (alginate-PLO-gelatin) hydrogel sheet with a groove pattern for use as a cell delivery platform. In addition, we demonstrate the topographical modification of the hydrogel sheet surface with a groove pattern to modulate cell proliferation, alignment, and elongation. We report that the patterned substrate prompted morphological changes of endothelial cells, increased cell-cell interaction, and resulted in the active secretion of growth factors such as PDGF-BB. Additionally, we incorporated magnetic nanoparticles (MNPs) into the patterned hydrogel sheet for the magnetic field-induced transfer of cell-seeded hydrogel sheets. As a result, enhanced wound healing was observed via efficient transplantation of the EPCs with an MNP-embedded patterned hydrogel sheet (MPS). Finally, enhanced vascularization and dermal wound repair were observed with EPC seeded MPS.
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