Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 4, Issue 12, Pages 4021-4027Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00986
Keywords
fluorescent silk fibroin; rare-earth upconverting phosphors; feeding; bioreactor; mass production
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Funding
- National Key Research and Development Program of China [2018YFC1105802/2018YFC1105800, 2016YFA0201702/2016YFA0201700]
- National Natural Science Foundation of China [21674018]
- Shanghai Education Development Foundation
- Shanghai Municipal Education Commission [15SG30]
- Youth Foundation of Donghua University [106-07-0053028]
- Fundamental Research Funds for the Central Universities
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Fluorescent silk fibroin (SF) fibers have great potential in biomedical application and special functions for marking and tracking. How to fabricate fluorescent SF fibers with good fluorescence stability by a simple and environmentally friendly method has yet to be explored. Here, we successfully produced fluorescent SF fibers by using silkworms as bioreactors to introduce rare-earth upconverting phosphors (UCPs) into silk fibroin. The modified silk exhibited bright green colors under 980 nm laser. This directly feeding method to produce fluorescent SF fibers is green and environmentally friendly and easy to use for mass production. Moreover, it provides an idea that SF fibers can be cooperated with more fluorescent materials which could exhibit different colors with a certain wavelength of light for broad application.
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