Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 5, Issue 2, Pages 959-969Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b01331
Keywords
fibrin hydrogel; inducible; injectable; microparticle; nitric oxide; PEG-NHS
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Funding
- National Institutes of Health [R15GM112082, R15GM104846]
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Fibrin microparticles were incorporated into poly(ethylene) glycol (PEG)-fibrinogen hydrogels to create an injectable composite that could serve as a wound healing support and vehicle to deliver therapeutic factors for tissue engineering. Nitric oxide (NO), a therapeutic agent in wound healing, was loaded into fibrin microparticles by blending S-nitroso-N-acetyl penicillamine (SNAP) with a fibrinogen solution. The incorporation of microparticles affected swelling behavior and improved tissue adhesivity of composite hydrogels. Controlled NO release was induced via photolytic and thermal activation, and modulated by weight percent of particles incorporated. These NO-releasing composites were noncytotoxic in culture. Cells maintained morphology, viability, and proliferative character. Fibrin microparticles loaded with SNAP and incorporated into a PEG-fibrinogen matrix creates a novel injectable composite hydrogel that offers improved tissue adhesivity and inducible NO-release for use as a regenerative support for wound healing and tissue engineering applications.
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