Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1855, Issue 2, Pages 123-130Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2015.01.002
Keywords
Tumor-associated macrophages; Tumor microenvironments; Anti-cancer therapy; CSF-1 receptor inhibitor
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Ministry of Health, Labor and Welfare
- Grants-in-Aid for Scientific Research [25293089, 26290050] Funding Source: KAKEN
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Tumor-associated macrophages are a critical component of tumor microenvironments, which affect tumor growth, tumor angiogenesis, immune suppression, metastasis and chemoresistance. There is emerging evidence that many anticancer modalities currently used in the clinic have unique and distinct properties that modulate the recruitment polarization and tumorigenic activities of macrophages in the tumor microenvironments. Educated tumor-associated macrophages significantly impact the clinical efficacies of and resistance to these anticancer modalities. Moreover, the development of drugs targeting tumor-associated macrophages, especially c-Fms kinase inhibitors and humanized antibodies targeting colony-stimulating factor-1 receptor, are in early clinical stages and show promising benefit for cancer patients. These experimental and clinical findings prompted us to further evaluate the potential targets that exhibit tumorigenic and immunosuppressive potential in a manner specific for tumor associated macrophages. (C) 2015 Elsevier B.V. All rights reserved.
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