Journal
GENES
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/genes9120597
Keywords
brain-specific angiogenesis inhibitor; apoptotic cell clearance; tumorigenesis; engulfment
Categories
Funding
- National Research Foundation (NRF) - Korea government (MSIT) [2017R1A2B1005773]
- National Research Foundation of Korea [2017R1A2B1005773] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Brain-specific angiogenesis inhibitors (BAIs) 1, 2, and 3 are members of the adhesion G protein-coupled receptors, subfamily B, which share a conserved seven-transmembrane structure and an N-terminal extracellular domain. In cell- and animal-based studies, these receptors have been shown to play diverse roles under physiological and pathological conditions. BAI1 is an engulfment receptor and performs major functions in apoptotic-cell clearance and interacts (as a pattern recognition receptor) with pathogen components. BAI1 and -3 also participate in myoblast fusion. Furthermore, BAI1-3 have been linked to tumor progression and neurological diseases. In this review, we summarize the current understanding of the functions of BAI1-3 in pathological and physiological conditions and discuss future directions in terms of the importance of BAIs as pharmacological targets in diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available