Journal
GENES
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/genes9120596
Keywords
N-6-methyladenosine; mRNA m(6)A methyltransferase (MTA); MTB; FIP37; ALKBH; YTDHF; Arabidopsis
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Funding
- KNOW Poznan RNA Centre [01/KNOW2/2014]
- Polish National Science Centre [UMO-2017/27/N/NZ1/00202, UMO-2016/23/B/NZ9/00862, UMO-2013/10/A/NZ1/00557]
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N-6-methyladenosine (m(6)A) is known to occur in plant and animal messenger RNAs (mRNAs) since the 1970s. However, the scope and function of this modification remained un-explored till very recently. Since the beginning of this decade, owing to major technological breakthroughs, the interest in m(6)A has peaked again. Similar to animal mRNAs, plant mRNAs are also m(6)A methylated, within a specific sequence motif which is conserved across these kingdoms. m(6)A has been found to be pivotal for plant development and necessary for processes ranging from seed germination to floral development. A wide range of proteins involved in methylation of adenosine have been identified alongside proteins that remove or identify m(6)A. This review aims to put together the current knowledge regarding m(6)A in Arabidopsis thaliana.
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