Journal
GENES
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/genes10010013
Keywords
RNA editing; epitranscriptome; neurological disorders; AID/APOBEC
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Funding
- ERC [649019]
- COST action [CA16120]
- European Research Council (ERC) [649019] Funding Source: European Research Council (ERC)
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One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease.
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