Journal
GENES
Volume 9, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/genes9120633
Keywords
histone methylation; acetylation; immunotherapy; cancer
Categories
Funding
- National Natural Science Foundation of China [81572947, 81673652, 81773216]
- Natural Science Foundation of Liaoning Province [20170540841, 20180550076]
- Scientific Research Fund of Liaoning Provincial Education Department [2017LFW01]
- Science Foundation of Shenyang Pharmaceutical University [DFJJ2018210]
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In the nucleus of each cell, the DNA is wrapped around histone octamers, forming the so-called nucleosomal core particles The histones undergo various modifications that influence chromatin structure and function, including methylation, acetylation, ubiquitination, phosphorylation, and SUMOylation. These modifications, known as epigenetic modifications (defined as heritable molecular determinants of phenotype that are independent of the DNA sequence), result in alterations of gene expression and changes in cell behavior. Recent work has shown that epigenetic drugs targeting histone deacetylation or methylation modulate the immune response and overcome acquired resistance to immunotherapy. A number of combination therapies involving immunotherapy and epigenetic drugs, which target histone deacetylation or methylation, are currently under various clinical/pre-clinical investigations and have shown promising anticancer efficacy. These combination therapies may provide a new strategy for achieving sustained anticancer efficacy and overcoming resistance.
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