Journal
FRONTIERS IN PHYSIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.01518
Keywords
arrhythmias; reactive oxygen species; oxidative stress; mitochondria; diabetes
Categories
Funding
- NIH [R01 HL137259, R21 AG054211, R21 HL114378, R01 HL113497]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL113497, R21HL114378, R01HL137259] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R21AG054211] Funding Source: NIH RePORTER
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The mitochondrial translocator protein (TSPO) is a key outer mitochondrial membrane protein that regulates the activity of energy-dissipating mitochondrial channels in response to oxidative stress. In this article, we provide an overview of the role of TSPO in the systematic amplification of reactive oxygen species (ROS) through an autocatalytic process known as ROS-induced ROS-release (RIRR). We describe how this TSPO-driven process destabilizes the mitochondrial membrane potential leading to electrical instability at the cellular and whole heart levels. Finally, we provide our perspective on the role of TSPO in the pathophysiology of diabetes, in general and diabetes-related arrhythmias, in particular.
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