Journal
FRONTIERS IN PHYSIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.01414
Keywords
gap junction; pannexin; connexin; invertebrates; channels; hemichannels
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Funding
- MINEDUC-UA project [ANT 1755]
- Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [1150291]
- ICM-Economia Centro Interdisciplinario de Neurociencias de Valparaiso [P09-022-F]
- CONICYT-Ph.D. fellowship, Chile
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The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes. Pioneer studies conducted mainly in worms and flies have shown that innexins participate in embryo development and behavior. However, recent studies have elucidated new functions of innexins in Arthropoda, Nematoda, Annelida, and Cnidaria, such as immune response, and apoptosis. This review describes emerging data of possible new roles of innexins and summarizes the data available to date.
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