Journal
CURRENT UROLOGY REPORTS
Volume 20, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s11934-019-0866-8
Keywords
Clear cell renal cell carcinoma; Immune checkpoint inhibition; PD-1; PD-L1; Immunohistochemistry; Sampling protocols; Targeted therapy
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Purpose of Review Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life. Recent Findings Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. Summary We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine.
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