4.6 Review

About Solid Phase vs. Liquid Phase in Suzuki-Miyaura Reaction

Journal

CATALYSTS
Volume 9, Issue 1, Pages -

Publisher

MDPI
DOI: 10.3390/catal9010060

Keywords

C-C coupling; Suzuki-Miyaura; homogeneous; heterogeneous; leaching

Funding

  1. Ecole Doctorale de Chimie de Lyon

Ask authors/readers for more resources

A critical review of conclusions about the putative heterogeneous mechanism in the Suzuki-Miyaura coupling by supported Pd solids is reported. In the first section, the turnover frequencies (TOF) of 20 well-established homogeneous catalysts are shown to be in the range 200 to 1,000,000,000 h(-1). The evidences used to prove a heterogeneous mechanism are discussed and another interpretation is proposed, hypothesizing that only the leached species are responsible for the catalytic reaction, even at ppb levels. Considering more than 40 published catalytic systems for which liquid phase Pd content have been reported, activities have been computed based on leached Pd concentrations and are shown to be in the range TOF 150 to 70,000,000 h(-1). Such values are compatible with those found for the well-established homogeneous catalysts which questions the validity of the conclusions raised by many papers about the heterogeneous (solid) nature of Suzuki-Miyaura catalysis. Last, a tentative methodology is proposed which involves the rational use of well-known tests (hot-filtration test, mercury test...) to help to discriminate between homogeneous and heterogeneous mechanisms.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available