Journal
CATALYSTS
Volume 8, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/catal8120640
Keywords
oxidation; molecular oxygen; metal catalysts; aryl ketones; benzoate esters; benzamides
Categories
Funding
- Basque Government [IT-774-13]
- Spanish Ministry of Economy and Competitiveness [CTQ2017-86630-P]
Ask authors/readers for more resources
Csp(3)-H oxidation of benzylic methylene compounds is an established strategy for the synthesis of aromatic ketones, esters, and amides. The need for more sustainable oxidizers has encouraged researchers to explore the use of molecular oxygen. In particular, homogeneous metal-catalyzed aerobic oxidation of benzylic methylenes has attracted much attention. This account summarizes the development of this oxidative strategy in the last two decades, examining key factors such as reaction yields, substrate: catalyst ratio, substrate scope, selectivity over other oxidation byproducts, and reaction conditions including solvents and temperature. Finally, several mechanistic proposals to explain the observed results will be discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available