Journal
BIOLOGY OPEN
Volume 8, Issue 1, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/bio.036822
Keywords
Asexual replication; Centrin; Centriolar plaque; Closed mitosis; Microtubule-organizing centre (MTOC); Plasmodium; Spindle pole body
Categories
Funding
- Medical Research Council [G0900109, G0900278, MR/K011782/1]
- Biotechnology and Biological Sciences Research Council [BB/N017609/1, BB/L013827/1]
- European Molecular Biology Organisation (EMBO)-Long Term fellowship [5972014]
- Francis Crick Institute from Cancer Research UK [FC001097]
- UK Medical Research Council [FC001097]
- Wellcome Trust [FC001097]
- BBSRC [BB/L013827/1, BB/N017609/1] Funding Source: UKRI
- MRC [MR/N023048/1, G0900278, MR/K011782/1, G0900109] Funding Source: UKRI
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Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also major components of the basal body of flagella and cilia. In Plasmodium spp., the parasite that causes malaria, mitosis is dosed during asexual replication and the MTOC is embedded within the intact nuclear membrane. The MTOC has been named the centriolar plaque and is similar to the spindle pole body in yeast. In all phases of asexual replication, repeated rounds of nuclear division precede cell division. However, our knowledge of the location and function of centrins during this process is limited. Previous studies have identified four putative centrins in the human parasite Plasmodium falciparum. We report here the cellular localization of an alveolate-specific centrin (PbCEN-4) during the atypical cell division of asexual replicative stages, using live cell imaging with the rodent malaria parasite P. berghei as a model system. We show that this centrin forms a multi-protein complex with other centrins, but is dispensable for parasite proliferation.
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