Journal
ACTA TROPICA
Volume 164, Issue -, Pages 77-83Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.actatropica.2016.08.025
Keywords
Toxoplasma gondii; Virus-like particle; Inner membrane complex; Vaccine; Protection
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Funding
- National Research Foundation of Korea (NRF) [NRF-2014R1A2A2A01004899]
- Ministry of Health & Welfare, Republic of Korea [HI15C2928]
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The inner membrane complex sub-compartment has a critical role in Toxoplasma gondii endodyogeny. In this study, we investigated the protection upon intraperitoneal route (IP) challenge induced by the virus-like particles (VLPs) vaccine containing Toxoplasma gondii IMC ISP (RH strain) (Type I). Intranasal immunization with the VLPs in mice elicited enhanced systemic and mucosal Toxoplasma gondii-specific IgG, IgG1, IgG2a and IgA antibody responses, and CD4+ and CD8+ responses. Immunized mice significantly reduced T. gondii cyst burden and size in brain, resulting in cross-protection upon T. gondii (ME49) (Type II) challenge infection. These results indicate that the IP route challenge infection induced by T. gondii IMC ISP VLPs might be a very good target for vaccination representing novel approach to reduce infection. (C) 2016 Elsevier B.V. All rights reserved.
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