Journal
MICROMACHINES
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/mi9110594
Keywords
acoustic trapping; ultrasonic manipulation; tissue engineering; tissue modelling; acoustofluidics; microfluidics
Categories
Funding
- Swedish Research Council
- Stockholm County Council
- Olle Engqvist Byggmastare Foundation
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Systems and devices for in vitro tissue modelling and engineering are valuable tools, which combine the strength between the controlled laboratory environment and the complex tissue organization and environment in vivo. Device-based tissue engineering is also a possible avenue for future explant culture in regenerative medicine. The most fundamental requirements on platforms intended for tissue modelling and engineering are their ability to shape and maintain cell aggregates over long-term culture. An emerging technology for tissue shaping and culture is ultrasonic standing wave (USW) particle manipulation, which offers label-free and gentle positioning and aggregation of cells. The pressure nodes defined by the USW, where cells are trapped in most cases, are stable over time and can be both static and dynamic depending on actuation schemes. In this review article, we highlight the potential of USW cell manipulation as a tool for tissue modelling and engineering.
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