Journal
MEDICAL SCIENCE MONITOR
Volume 24, Issue -, Pages 8767-8772Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.912528
Keywords
Cytokines; Purpura; Thrombocytopenic; Idiopathic; T-Lymphocytes; Helper-Inducer
Categories
Funding
- National Program on Key Basic Research Project (973 Program) [2015CB755402]
- Wu Jieping Medical Fund [320.6750.17181]
- Scientific Research Foundation of Qilu Hospital of Shandong University (Qingdao) [QDKY2015ZD07]
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Background: The disequilibrium of T helper (Th) cells play an important role in the occurrence and development of immune thrombocytopenic purpura (ITP). Th22 cells, as a newly discovered subset of T lymphocytes, plays an important role in autoimmune disorders and inflammatory diseases. Material/Methods: This study explored the role of different lymphocyte subsets in chronic ITP. To explore the value of Th22 cells in the diagnosis of ITP, the numbers of Th1, Th17, and Th22 cells were detected by a 4-color flow cytometric in 32 chronic ITP patients and 30 healthy controls. Results: Our data showed that, compared with healthy controls, the numbers of circulating Th1, Th17, and Th22 (p<0.05) cells increased significantly in ITP patients, and Th22 cells were correlated positively with Th1 cells (r=0.4041, p<0.01) and Th17 cells (r=0.4637, p<0.05). Moreover, a positive relationship was found between Th1/Th22 cells and Th1 cells (r=0.7696, p<0.001). Conclusions: A disequilibrium expression profile of Th22 cells in peripheral blood was associated with pathogenesis of ITP, possibly through cooperatively working with Th17 and Th1, which may provide a novel approach for diagnosis of ITP.
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