Journal
MEDICAL SCIENCE MONITOR
Volume 24, Issue -, Pages 8524-8532Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.911766
Keywords
Age Factors; Carcinoma, Signet Ring Cell; SEER Program; Stomach Neoplasms
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Funding
- Shanghai Committee of Science and Technology Funds [15411960300]
- Key Medical Specialty funded by the Fifth People's Hospital of Shanghai, Fudan University [2017WYZDZK01]
- Great Discipline Construction Project from the Medical System of Shanghai Minhang District [2017MWDXK01]
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Background: Age is a prognostic factor for multiple malignancies. In this study, we aimed to assess the effect of age on the cancer-specific survival (CSS) of patients with gastric signet-ring cell carcinoma (SRC). Material/Methods: Information on patients with gastric SRC was extracted from the Surveillance, Epidemiology, and End Results database. Chi-squared tests were used to demonstrate distribution differences, and Kaplan-Meier analysis and Cox regression models were used to analyze the impact of age on CSS. Results: A total of 4596 patients were enrolled and divided into 3 subgroups according to age (<45, 45-74, and >74 years old). Higher percentages of T4, N2, and M1 disease were observed in the <45-year-old group (all P<0.001). Kaplan-Meier plots showed that the youngest group had the most favorable 5-year CSS rate (36.3%), which remained true after stratification according to tumor stage. Multivariate Cox regression models demonstrated a poorer survival outcome for >74-year-old than for <45-year-old patients (hazard ratio 1.841, 95% confidence interval 1.636-2.071; P<0.001). Conclusions: Young age is associated with improved survival, even though younger patients generally present with a more advanced-stage disease.
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