Journal
MEDICAL SCIENCE MONITOR
Volume 24, Issue -, Pages 8172-8182Publisher
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.913479
Keywords
Breast Neoplasms; Cell Migration Assays; Focal Adhesion Kinase 2; Neoplasm Invasiveness
Categories
Funding
- National Natural Science Foundation of China [81260323]
- First People's Hospital of Yunnan Province, P.R. China [2016NS226]
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Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival, proliferation, migration, invasion, metastasis, and chemo-resistance, and is associated with poor prognosis and shortened survival in various cancer types. Thus, Pyk2 has been traditionally regarded as an oncogene and potential therapeutic target for cancers. However, a few studies have also demonstrated that Pyk2 exerts tumor-suppressive effects in some cancers, and anticancer treatment of Pyk2 inhibitors may only achieve marginal benefits in these cancers. Therefore, more detailed knowledge of the contradictory functions of Pyk2 is needed. In this review, we summarized the tissue distribution, expression, interactive molecules of Pyk2 in the signaling pathway, and roles of Pyk2 in cancers, and focused on regulation of the interconnectivity between Pyk2 and its downstream targets. The potential use of inhibitors of Pyk2 and its related pathways in cancer therapy is also discussed.
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