Journal
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
Volume 9, Issue 5, Pages 860-870Publisher
WILEY
DOI: 10.1002/jcsm.12333
Keywords
Sarcopenia; Prognosis; Portal hypertension; HVPG; MELD
Funding
- National Research Foundation of Korea - Korea government [2017R1A2B4009199, 2017R1A5A2015369, 2018R1C1B5044890]
- National Research Foundation of Korea [2017R1A2B4009199, 2018R1C1B5044890, 2017R1A5A2015369] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Background Sarcopenia has been reported as a prognostic factor. We evaluated the impact of sarcopenia to the conventional prognostic factors [Model for End-Stage Liver Disease (MELD) score, Child-Turcotte-Pugh (CTP) score, hepatic venous pressure gradient (HVPG)] in cirrhosis. Methods Overall, 452 patients with cirrhosis were stratified by MELD score (low < 15, high >= 15), CTP class, and HVPG [nonclinically significant portal hypertension (CSPH), 6-9 mmHg; CSPH, 10-19 mmHg; extremely severe PH, 20 mmH >= g]. L3 skeletal muscle index as marker of sarcopenia was subdivided into quartiles (47.01-52.25-58.22 cm(2)/m(2)). Results Among the patients, 42% (190/452) presented with sarcopenia. During a median follow-up period of 21.2 months, sarcopenia was associated with mortality (adjusted hazard ratio=2.253, P<0.001) and specifically with compensated and early decompensated stages of cirrhosis, but not with advanced decompensated stages; low (P<0.001) and high (P=0.095) MELD scores; CTP classes A (P=0.034), B (P<0.001), and C (P=0.205); and non-CSPH (P=0.018), CSPH (P<0.001), and extremely severe PH (P=0.846). In quartiles of sarcopenia, MELD score, CTP class, and HVPG were independent predictors of mortality in non-sarcopenia, but not in severe sarcopenia (MELD, P=0.182; CTP, P=0.187; HVPG, P=0.077). Conclusions Sarcopenia is associated with mortality in compensated and early decompensated cirrhosis, and existing conventional prognostic factors had limited value in severe sarcopenia. Therefore, incorporating sarcopenia in the conventional prognostic factors had added value, particularly in compensated and early decompensated cirrhosis. Subclassification of prognostic factors according to sarcopenia may help to better assess the prognosis of cirrhosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available