Journal
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Volume 7, Issue 23, Pages -Publisher
WILEY
DOI: 10.1161/JAHA.118.008870
Keywords
birth weight; cardiovascular disease; hypertension; type 2 diabetes mellitus
Categories
Funding
- National University of Singapore [R-608-000-139-133]
- Singapore Ministry of Education [R-608-000-161-114]
- Beijing Technology and Business University Grant [88442Y0033]
- Peking University [71013Y0026]
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Background-Low birth weight has been associated with increased risk of type 2 diabetes mellitus, cardiovascular disease, and hypertension, but the risk at high birth weight levels remains uncertain. This systematic review and meta-analysis aimed to clarify the shape of associations between birth weight and aforementioned diseases in adults and assessed sex-specific risks. Methods and Results-We systematically searched PubMed, EMBASE, and Web of Science for studies published between 1980 and October 2016. Studies of birth weight and type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and hypertension were included. Random-effects models were used to derive the summary relative risks and corresponding 95% confidence intervals. We identified 49 studies with 4 053 367 participants assessing the association between birth weight and T2DM, 33 studies with 5 949 477 participants for CVD, and 53 studies with 4 335 149 participants for hypertension and high blood pressure. Sex-specific binary analyses showed that only females had an increased risk of T2DM and CVD at the upper tail of the birth weight distribution. While categorical analyses of 6 birth weight groups and dose-response analyses showed J-shaped associations of birth weight with T2DM and CVD, the association was inverse with hypertension. The lowest risks for T2DM, CVD, and hypertension were observed at 3.5 to 4.0, 4.0 to 4.5, and 4.0 to 4.5 kg, respectively. Conclusions-These findings indicate that birth weight is associated with risk of T2DM and CVD in a J-shaped manner and that this is more pronounced among females.
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