Journal
ELIFE
Volume 7, Issue -, Pages -Publisher
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.39887
Keywords
-
Categories
Funding
- European Commission ERC Consolidator [614880]
- Agence Nationale de la Recherche LabEx ParaFrap [ANR-11-LABX-0024]
- Agence Nationale de la Recherche [ANR-12-JSV3-0004-01]
- Agence Nationale de la Recherche (ANR) [ANR-12-JSV3-0004] Funding Source: Agence Nationale de la Recherche (ANR)
- European Research Council (ERC) [614880] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host processes by delivering effector proteins into the host cell that shift gene expression in a timely fashion. We identified a parasite dense granule protein as GRA18 that once released in the host cell cytoplasm forms versatile complexes with regulatory elements of the beta-catenin destruction complex. By interacting with GSK3/PP2A-B56, GRA18 drives beta-catenin up-regulation and the downstream effects on host cell gene expression. In the context of macrophages infection, GRA18 induces the expression of a specific set of genes commonly associated with an anti-inflammatory response that includes those encoding chemokines CCL17 and CCL22. Overall, this study adds another original strategy by which T. gondii tachyzoites reshuffle the host cell interactome through a GSK3/beta-catenin axis to selectively reprogram immune gene expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available