Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 46, Issue -, Pages S725-S733Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2018.1508030
Keywords
Nanoparticles; magnetic mesoporous silica; cancer; oncology; smart device
Categories
Funding
- National Scientific and Technological Research Council (CNPQ)
- Rio de Janeiro State Research Foundation (FAPERJ)
- Ministerio de Economia y Competitividad [MAT2012-38429-C04-01]
- Generalitat Valenciana [PROMETEO/2009/016]
Ask authors/readers for more resources
Breast cancer is women's most common type of cancer, with a global rate of over 522,000 deaths per year. One of the main problems related to breast cancer relies in the early detection, as the specialized treatment. In this direction was developed, characterized and tested in vivo a smart delivery system, based on radiolabelled magnetic core mesoporous silica doped with trastuzumab as intralesional nanodrug for breast cancer imaging and possible therapy. The results showed that nanoparticles had a size of 58.98.1nm, with specific surface area of 872 m(2)/g and pore volume of 0.85cm(3)/g with a pore diameter of 3.15nm. The magnetic core mesoporous silica was efficiently labelled with 99mTc (97.5% +/- 0.8) and doped >98%. The cytotoxicity assay, demonstrated they are safe to use. The data were corroborated with the IC50 result of: 829.6 mu g +/- 43.2. The biodistribution showed an uptake by the tumour of 7.5% (systemic via) and 97.37% (intralesional) with less than 3% of these nanoparticles absorbed by healthy tissues. In a period 6-h post-injection, no barrier delimited by the tumour was crossed, corroborating the use as intralesional nanodrug. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available