Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 47, Issue 1, Pages 30-44Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2018.1541900
Keywords
Ginsenoside CK; gold nanoparticles; photothermal therapy; photoluminescence; drug delivery; green synthesis; anticancer activity
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Funding
- Nano Conversion Foundation - Ministry of Science and ICT (MSIT, Korea)
- Ministry of Trade, Industry and Energy (MOTIE, Korea) [R201800510]
- Cooperative Research Program for Agriculture Science and Technology Development Rural Development Administration, Republic of Korea [PJ0128132017]
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We report a non-covalent loading of ginsenoside compound K (CK) onto our previously reported gold nanoparticles (DCY51(T)-AuCKNps) through one-pot biosynthesis using a probiotic Lactobacillus kimchicus DCY51(T) isolated from Korean kimchi. The ginsenoside-loaded gold nanoparticles were characterized by various analytical and spectroscopic techniques such as field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), Fourier-transform infrared (FTIR) spectroscopy and dynamic light scattering (DLS). Furthermore, drug loading was also determined by liquid chromatography-mass spectrometry (LC-MS). In addition, DCY51(T)-AuNps and DCY51(T)-AuCKNps were resistant to aggregation caused by pH variation or a high ionic strength environment. Cell-based study confirmed that DCY51(T)-AuCKNps exhibited slightly higher cytotoxicity compared to ginsenoside CK treatment in A549 cells (human lung adenocarcinoma cell line) and HT29 (human colorectal adenocarcinoma cell line). Upon laser treatment, DCY51(T)-AuCKNps showed enhanced cell apoptosis in A549, HT29 and AGS cells (human stomach gastric adenocarcinoma cell line) compared with only DCY51(T)-AuCKNps treated cells. In conclusion, this preliminary study identified that DCY51(T)-AuCKNps act as a potent photothermal therapy agents with synergistic chemotherapeutic effects for the treatment of cancer.
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