Journal
WILEY INTERDISCIPLINARY REVIEWS-RNA
Volume 10, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/wrna.1520
Keywords
gastrointestinal cancer; posttranscriptional gene regulation; RNA-binding protein
Categories
Funding
- JSPS KAKENHI
- Gastrointestinal Cancer Project - Nakayama Cancer Research Institute
- Taiho Pharmaceutical, Inc.
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Gene expression patterns in cancer cells are strongly influenced by posttranscriptional mechanisms. RNA-binding proteins (RBPs) play key roles in posttranscriptional gene regulation; they can interact with target mRNAs in a sequence- and structure-dependent manner, and determine cellular behavior by manipulating the processing of these mRNAs. Numerous RBPs are aberrantly deregulated in many human cancers and hence, affect the functioning of mRNAs that encode proteins, implicated in carcinogenesis. Here, we summarize the key roles of RBPs in posttranscriptional gene regulation, describe RBPs disrupted in cancer, and lastly focus on RBPs that are responsible for implementing cancer traits in the digestive tract. These evidences may reveal a potential link between changes in expression/function of RBPs and malignant transformation, and a framework for new insights and potential therapeutic applications. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications
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