Journal
POLYMERS
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/polym10121379
Keywords
implants; drug delivery; design; manufacture
Categories
Funding
- Department for the Economy (Northern Ireland) studentship
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The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.
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