Journal
POLYMERS
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/polym10101165
Keywords
polymer brushes; calcium phosphate; hydroxyapatite; carbonated apatite; bone mimic; biocompatibility; Dictyostelium discoideum
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Funding
- European Science Foundation (Precision Polymer Materials P2M) [4701]
- Karlsruhe Micro- and Nano Facility [2015-014-007830]
- University of Potsdam
- TEAM program of the Foundation for Polish Science - European Union under the European Regional Development Fund [TEAM/2016-1/9]
- Federal Ministry of Economics and Technology
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This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
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