Journal
PLOS BIOLOGY
Volume 16, Issue 10, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.2005264
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Funding
- Canadian Institutes of Health Research (CIHR) [MOP-14828]
- CIHR
- Fonds de recherche du Quebec Sante
- Heart and Stroke Foundation of Canada
- NIH intramural program
- MRC [MR/L003384/1, MR/R001316/1]
- MRC [MR/R001316/1, MR/L003384/1, UKDRI-4005] Funding Source: UKRI
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Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macro-phages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery. We suggest that macrophages entering the CNS provide a regulatory mechanism that controls acute and long-term microglia-mediated inflammation, which may drive damage in a variety of CNS conditions.
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