Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1853, Issue 11, Pages 3153-3164Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2015.04.015
Keywords
Mechanotransduction; Cytoskeleton; Biomechanics; Cell mechanics; Tendinopathy; Diastolic dysfunction
Categories
Funding
- GAANN [P200A120246, T32 GM-07229, T32-HL007843]
- NIH [U01EB016633, R01EB017753]
- NSF
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The extracellular matrix (ECM) is a major component of the biomechanical environment with which cells interact, and it plays important roles in both normal development and disease progression. Mechanical and biochemical factors alter the biomechanical properties of tissues by driving cellular remodeling of the ECM. This review provides an overview of the structural, compositional, and mechanical properties of the ECM that instruct cell behaviors. Case studies are reviewed that highlight mechanotransduction in the context of two distinct tissues: tendons and the heart. Although these two tissues demonstrate differences in relative cell-ECM composition and mechanical environment, they share similar mechanisms underlying ECM dysfunction and cell mechanotransduction. Together, these topics provide a framework for a fundamental understanding of the ECM and how it may vary across normal and diseased tissues in response to mechanical and biochemical cues. This article is part of a Special Issue entitled: Mechanobiology. (C) 2015 Published by Elsevier B.V.
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