Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1853, Issue 4, Pages 775-780Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2014.09.019
Keywords
MHC class II; Lipid raft; T lymphocyte; Antigen presenting cell
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Funding
- National Cancer Institute
- U.S. Food and Drug Administration
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MHC class II (MHC-II) molecules function by binding peptides derived from either self or foreign proteins and expressing these peptides on the surface of antigen presenting cells (APCs) for recognition by CD4T cells. MHC-II is known to exist on clusters on the surface of APCs, and a variety of biochemical and functional studies have suggested that these clusters represent lipid raft microdomain-associated MHC-II. This review will summarize data exploring the biosynthesis of raft-associated MHC-II and the role that lipid raft association plays in regulating T cell activation by APCs. This article is part of a Special Issue entitled: Nanoscale membrane organisation and signalling. Published by Elsevier B.V.
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