Journal
ACTA PHARMACOLOGICA SINICA
Volume 37, Issue 4, Pages 425-443Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2015.145
Keywords
endoplasmic reticulum stress; unfolded protein response; ischemic cardiomyopathy; atherosclerosis; hypertension; cardiac hypertrophy; heart failure
Funding
- National Natural Science Foundation of China [81270420, 81470434, 81503074]
- Hunan Provincial Natural Science Foundation of China [14JJ3102]
- Construct Program of the Key Discipline in Human Province
- Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study (Hunan Provincial Education Department) [2014-405]
- China Postdoctoral Science Foundation [2014M560647, 2015T80875]
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Endoplasmic reticulum is a principal organelle responsible for folding, post-translational modifications and transport of secretory, luminal and membrane proteins, thus palys an important rale in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) is a condition that is accelerated by accumulation of unfolded/misfolded proteins after endoplasmic reticulum environment disturbance, triggered by a variety of physiological and pathological factors, such as nutrient deprivation, altered glycosylation, calcium depletion, oxidative stress, DNA damage and energy disturbance, etc. ERS may initiate the unfolded protein response (UPR) to restore cellular homeostasis or lead to apoptosis. Numerous studies have clarified the link between ERS and cardiovascular diseases. This review focuses on ERS-associated molecular mechanisms that participate in physiological and pathophysiological processes of heart and blood vessels. In addition, a number of drugs that regulate ERS was introduced, which may be used to treat cardiovascular diseases. This review may open new avenues for studying the pathogenesis of cardiovascular diseases and discovering novel drugs targeting ERS.
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