Journal
G3-GENES GENOMES GENETICS
Volume 9, Issue 2, Pages 453-462Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.118.200809
Keywords
Drosophila; GAL4; neuromuscular junction; NMJ; synaptic boutons; glutamatergic synapse; motor neuron
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Funding
- UK Biotechnology and Biological Sciences Research Council [BB/L021706/1]
- European Union Horizon 2020 research and innovation program [745007]
- BBSRC [BB/L021706/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [745007] Funding Source: Marie Curie Actions (MSCA)
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The Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system. There are two main Types of glutamatergic motor neurons, Ib and Is, with different structural and physiological properties at synaptic level at the neuromuscular junction. To generate genetic tools to identify and manipulate motor neurons of each Type, we screened for GAL4 driver lines for this purpose. Here we describe GAL4 drivers specific for examples of neurons within each Type, Ib or Is. These drivers showed high expression levels and were expressed in only few motor neurons, making them amenable tools for specific studies of both axonal and synapse biology in identified Type I motor neurons.
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