Journal
ACTA PHARMACOLOGICA SINICA
Volume 37, Issue 7, Pages 1002-1012Publisher
ACTA PHARMACOLOGICA SINICA
DOI: 10.1038/aps.2016.54
Keywords
non-steroidal anti-inflammatory drug; diclofenac; ciprofloxacin; pharmacokinetics; enterohepatic circulation; beta-glucuronidase; enteropathy; drug-drug inetraction
Funding
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Policy Directive Program of Jiangsu Province [BY2015072-03]
Ask authors/readers for more resources
Aim: Diclofenac is a non-steroidal anti-inflammatory drug (NSAID), which may cause serious intestinal adverse reactions (enteropathy). In this study we investigated whether co-administration of ciprofloxacin affected the pharmacokinetics of diclofenac and diclofenac-induced enteropathy in rats. Methods: The pharmacokinetics of diclofenac was assessed in rats after receiving diclofenac (10 mg/kg, ig, or 5 mg/kg, iv), with or without ciprofloxacin (20 mg/kg, ig) co-administered. After receiving 6 oral doses or 15 intravenous doses of diclofenac, the rats were sacrificed, and small intestine was removed to examine diclofenac-induced enteropathy. beta-Glucuronidase activity in intestinal content, bovine liver and E coli was evaluated. Results: Following oral or intravenous administration, the pharmacokinetic profile of diclofenac displayed typical enterohepatic circulation, and co-administration of ciprofloxacin abolished the enterohepatic circulation, resulted in significant reduction in the plasma content of diclofenac. In control rats, beta-glucuronidase activity in small intestinal content was region-dependent: proximal intestine
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available